Abnormal NK Cell Lymphocytosis Detected after Splenectomy: Association with Repeated Infections, Relapsing Neutropenia, and Persistent Polyclonal B-Cell Proliferation
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چکیده
منابع مشابه
Abnormal NK cell lymphocytosis detected after splenectomy: association with repeated infections, relapsing neutropenia, and persistent polyclonal B-cell proliferation.
We report the case of a boy with hereditary spherocytosis who presented with mild microcytic hypochromic anemia and recurrent leg ulcers that had been present since childhood. Chronic natural killer (NK) cell and B-cell lymphocytosis was detected 1 year after therapeutic splenectomy during investigation of recurrent episodes of neutropenia and persistent lymphocytosis. NK cells proved to be abn...
متن کاملPersistent polyclonal B-cell lymphocytosis.
Persistent polyclonal B-cell lymphocytosis (PPBL) is a rare and recently described entity. PPBL is diagnosed predominantly but not exclusively in women, usually smokers and is characterized by a moderate, chronic and absolute lymphocytosis (> 4 x 109/L). Peripheral blood examination show in all cases atypical binucleated lymphocytes. A polyclonal serum IgM is also associated and HLA-DR7 express...
متن کاملPersistent polyclonal B-cell lymphocytosis.
We document a case of persistent lymphocytosis in which the characteristic binucleated circulating lymphocytes were shown immunologically to be polyclonal B-cells. Cytogenetic and molecular studies failed to show a clonal population. A review of the literature on this rare condition, persistent polyclonal B-cell lymphocytosis, highlights an association with the female sex, HLA-DR7 antigen, smok...
متن کاملSymptomatic Massive Splenomegaly in Persistent Polyclonal B-cell Lymphocytosis Requiring Splenectomy
INTRODUCTION Persistent polyclonal B-cell lymphocytosis (PPBL) is a rare lymphoproliferative hematological disease characterized by binucleated lymphocytes, CD 19+ CD 5-lymphocytosis, and elevated levels of serum immunoglobulin M (IgM). It can rarely be associated with splenomegaly, though the disease usually remains indolent. CASE PRESENTATION We present a case of PPBL in a young man with ma...
متن کاملBilobulated circulating lymphocytes in persistent polyclonal B-cell lymphocytosis.
Correspondence: Lourdes Florensa, MD, Laboratori de Citologia Hematològica, Laboratori de Referència de Catalunya, Hospital de l’Esperança, Av. Sant Josep de la Muntanya 12, 08024 Barcelona, Spain. Phone: international +34-93-285.02.00 ext 2189-2243 – Fax: international +34-93-210.84.06 – E-mail: [email protected] A44-year-old female was referred for investigation of a 10-year persistent lymph...
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ژورنال
عنوان ژورنال: International Journal of Hematology
سال: 2002
ISSN: 0925-5710,1865-3774
DOI: 10.1007/bf02982110